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Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling
Ahmad Abdullah1, Carl Herdenberg1, Håkan Hedman2,3
1Department of Radiation Sciences, Oncology, Umeå University, 90187, Umeå, Sweden.
Scientific Reports
|April 22, 2021
Summary
Netrin-1 suppresses bone morphogenetic protein (BMP) signaling, revealing a new role for this protein. This discovery, involving the neogenin receptor, may explain netrin-1
Area of Science:
- Molecular Biology
- Cell Signaling
- Developmental Biology
Background:
- Netrin-1 is known for axonal guidance and cancer metastasis.
- Molecular mechanisms of netrin-1 functions are not fully understood.
Purpose of the Study:
- To investigate the molecular mechanisms of netrin-1.
- To identify novel functions of netrin-1 in cellular signaling.
Main Methods:
- Investigated netrin-1's interaction with bone morphogenetic protein (BMP) signaling pathways.
- Utilized mouse embryonic fibroblasts to study netrin-1 receptor neogenin.
- Examined the interplay between netrin-1, leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins, and BMP signaling.
Main Results:
- Netrin-1 acts as a suppressor of BMP signaling.
- This suppression is mediated through the netrin receptor neogenin.
- Netrin-1 exhibits a mutually inhibitory interaction with LRIG proteins in regulating BMP signaling.
Conclusions:
- Netrin-1 has a previously unrecognized function as a BMP signaling suppressor.
- This finding provides insights into the signal transduction mechanisms underlying netrin-1's roles in development and disease.
- The interaction between netrin-1, neogenin, and LRIG proteins is crucial for regulating BMP signaling.
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