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Dietary supplementation with whey protein improves systemic microvascular function in heart failure patients: a pilot
A De Lorenzo1, E M Dos Santos1, A S Bello Moreira1,2
1Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, Brasil.
Summary
Whey protein (WP) supplementation improved microvascular function in heart failure (HF) patients. This dietary intervention enhanced both endothelial-dependent and independent vasodilation, suggesting potential benefits for cardiovascular health in HF populations.
Area of Science:
- Cardiovascular Physiology
- Nutritional Science
- Clinical Research
Background:
- Endothelial dysfunction is a key factor in heart failure (HF) pathophysiology.
- Whey protein (WP) is known for muscle mass benefits but has under-explored vascular effects.
- Systemic microvascular function is crucial for cardiovascular health in HF patients.
Purpose of the Study:
- To investigate the impact of 12-week whey protein (WP) supplementation on systemic microvascular function.
- To assess WP's effects on endothelial-dependent and independent vasodilation in heart failure (HF) patients.
- To evaluate WP as a potential dietary intervention for improving vascular health in HF.
Main Methods:
- Blinded, randomized, placebo-controlled clinical trial.
- 12-week dietary supplementation with WP or placebo (maltodextrin).
- Assessment of cutaneous microvascular reactivity using laser speckle contrast imaging and pharmacological stimuli (acetylcholine and sodium nitroprusside).
Main Results:
- Whey protein (WP) supplementation significantly improved endothelial-dependent vasodilation (P=0.03).
- WP supplementation also enhanced endothelial-independent vasodilation (P=0.04).
- No significant improvements were observed in the placebo group for either type of vasodilation.
Conclusions:
- Dietary whey protein (WP) supplementation positively impacts systemic microvascular function in heart failure (HF) patients.
- WP may offer a beneficial adjunctive therapy for improving vascular health in individuals with HF.
- Further research is warranted to explore the long-term cardiovascular benefits of WP in HF.
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