Related Experiment Video
Updated: Nov 8, 2025

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
Case report of Brunner's gland hyperplasia: A rare "mimic" of malignant pathology
Jonathan McCafferty1, Ashraf Tokhi2, Sujith Krishnamoorthy3
1Royal Melbourne Hospital, Melbourne, Australia.
Introduction:
Brunner's gland hyperplasia is a rare, benign lesion of the duodenum. The symptomology can range from asymptomatic (as an incidental finding on endoscopy) to gastrointestinal obstruction or haemorrhage.
Case Presentation:
We report a case of a 60-year-old man presenting with post-prandial vomiting and weight loss. Inpatient evaluation led to the likely diagnosis of a duodenal malignancy for which the patient underwent a laparotomy and proximal duodenectomy.
Clinical Discussion:
Brunner's gland hyperplasia is a rare, benign condition that can be overtreated due to the difficulty in obtaining an accurate pre-operative diagnosis. The literature has been reviewed to discuss the approach to diagnosis.
Conclusion:
This case highlights the potential for Brunner's gland hyperplasia mimicking a malignancy.

