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Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Updated: Nov 8, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

⁸⁶Y PET imaging.

Mariane Le Fur¹, Peter Caravan¹

¹The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.

Methods in Enzymology

|April 23, 2021

Summary

This summary is machine-generated.

Yttrium-86 (86Y) is a positron emitter useful for PET imaging, offering dosimetry data before yttrium-90 (90Y) therapy and tracking biochemical processes. This chapter details 86Y production, purification, radiolabeling, and purity assessment for PET applications.

Keywords:

Dosimetry Gadolinium HILIC Positron emission tomography Radiolabeling Radiopharmaceutical Theranostic Yttrium-86 Yttrium-90

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Area of Science:

Nuclear Medicine
Radiochemistry
Positron Emission Tomography (PET) Imaging

Background:

Yttrium-86 (86Y) is a positron-emitting isotope with potential in nuclear medicine.
It can offer pre-therapeutic dosimetry for Yttrium-90 (90Y) radiopharmaceuticals.
86Y enables the study of biochemical processes via PET imaging.

Purpose of the Study:

To discuss the production and purification methods for 86Y.
To highlight the applications of 86Y in PET imaging.
To present protocols for radiolabeling and assessing the radiochemical purity of 86Y-labeled compounds.

Main Methods:

Production and purification of 86Y.
Radiolabeling of chelating agents like DOTA and DTPA with 86Y.
Development of protocols for determining radiochemical purity of 86Y-DOTA and 86Y-DTPA.

Main Results:

Established methods for producing and purifying 86Y.
Demonstrated successful radiolabeling of DOTA and DTPA with 86Y.
Presented validated protocols for assessing the radiochemical purity of these 86Y-labeled agents.

Conclusions:

Yttrium-86 is a valuable radionuclide for PET imaging, bridging dosimetry and biochemical process monitoring.
The discussed production, purification, and radiolabeling methods facilitate its use in clinical and research settings.
Validated purity assessment protocols ensure the reliability of 86Y-based PET imaging studies.