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Risk Factors for Tigecycline-Associated Hypofibrinogenemia
Jia Liu1, Yingying Yan2, Fan Zhang1
1Department of Geriatrics, Peking University Third Hospital, Beijing, People's Republic of China.
Therapeutics and Clinical Risk Management
|April 23, 2021
Summary
Tigecycline can cause hypofibrinogenemia, especially in elderly patients. Risk factors include advanced age, prolonged treatment, and low baseline fibrinogen, increasing bleeding risk.
Area of Science:
- Pharmacology
- Clinical Medicine
- Hematology
Background:
- Tigecycline use is increasing, particularly in elderly patients with multidrug-resistant bacterial infections.
- Coagulation disorders associated with tigecycline are a growing clinical concern.
- Risk factors for tigecycline-associated hypofibrinogenemia remain debated.
Purpose of the Study:
- To identify factors related to tigecycline-induced hypofibrinogenemia.
- To develop risk assessment criteria for tigecycline-associated hypofibrinogenemia.
Main Methods:
- Observational retrospective cohort study.
- Included patients receiving tigecycline for at least 3 days.
- Hypofibrinogenemia defined as plasma fibrinogen <2.0 g/L; logistic regression and ROC curves used for analysis.
Main Results:
- 148 patients analyzed (mean age 77.09 years).
- Age (≥82 years), tigecycline duration (≥9 days), and baseline fibrinogen (≤3.5 g/L) independently predicted hypofibrinogenemia.
- Hypofibrinogenemia was linked to an increased risk of bleeding (OR 8.96).
Conclusions:
- Hypofibrinogenemia is a frequent tigecycline adverse effect, especially in the elderly.
- Identified risk criteria aid in detecting high-risk patients.
- Hypofibrinogenemia is associated with bleeding but not mortality.
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