Related Experiment Video

Updated: Nov 8, 2025

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence
08:02

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence

Published on: March 12, 2020

6.8K

Role of G Protein-Coupled Estrogen Receptor in Digestive System Carcinomas: A Minireview

Yu-An Qiu1, Jianping Xiong2, Tenghua Yu3

  • 1Department of Critical Care Medicine, Jiangxi Cancer Hospital, Nanchang University Cancer Hospital, Nanchang, 330029, People's Republic of China.

Oncotargets and Therapy
|April 23, 2021
PubMed

Insights

G protein-coupled estrogen receptor (GPER) is a key player in digestive system cancers. Research highlights GPER

Area of Science:

  • Oncology
  • Molecular Biology
  • Endocrinology

Background:

  • Digestive system carcinomas are a major global health concern.
  • G protein-coupled estrogen receptor (GPER) is implicated in various cancers.
  • GPER's role in digestive cancers is an emerging area of research.

Purpose of the Study:

  • To review the literature on GPER's function in digestive system carcinomas.
  • To explore GPER's potential as a biomarker for these cancers.
  • To discuss GPER's application in diagnostic and therapeutic strategies.

Main Methods:

  • Literature review of recent studies on GPER in digestive cancers.
  • Analysis of GPER's functional roles and clinical significance.
  • Synthesis of findings regarding GPER's biomarker potential.

Main Results:

  • GPER is increasingly recognized for its role in gastric, liver, pancreatic, and colorectal cancers.
  • Evidence suggests GPER's involvement in the progression of digestive system carcinomas.
  • GPER shows promise as a diagnostic and therapeutic target.

Conclusions:

  • GPER is a significant factor in digestive system carcinomas.
  • GPER holds potential as a biomarker for early detection and prognosis.
  • Targeting GPER may offer novel treatment avenues for digestive cancers.
Keywords:
GPERdigestive system carcinomasprognostic indicatortherapeutic target

More Related Videos

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

10.7K
Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay06:07

Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay

Published on: June 7, 2020

5.1K

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.3K
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
14.8K
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
3.1K
Regulation of the Digestive System01:25

Regulation of the Digestive System

Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of...
1.4K
Hormonal Regulation01:40

Hormonal Regulation

Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
45.5K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.4K