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Updated: Nov 8, 2025

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
"Multimodality imaging of the extrapleural space lesions"
Ravishankar Pillenahalli Maheshwarappa1, Maharshi Rajdev2, Prashant Nagpal1
1Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, USA.
The extrapleural space (EPS) is often overlooked on imaging. Understanding its anatomy and pathologies is crucial for accurate diagnosis and treatment planning in chest conditions.
Area of Science:
- Radiology
- Thoracic Imaging
- Medical Anatomy
Background:
- The extrapleural space (EPS), located between the parietal pleura and chest wall/diaphragm, is involved in various pathologies.
- Diseases of the EPS are frequently missed on imaging due to limited understanding of its anatomy and appearance.
- Recognizing EPS involvement is vital for appropriate treatment and malignancy staging.
Purpose of the Study:
- To provide a comprehensive overview of EPS anatomy and pathologies.
- To discuss the utility of various imaging modalities for EPS lesions.
- To highlight the role of cross-sectional imaging and emerging technologies like spectral CT in diagnosing EPS diseases.
Main Methods:
- Review of anatomical and pathological literature concerning the extrapleural space.
- Analysis of imaging findings for diverse EPS pathologies using conventional and advanced techniques.
- Emphasis on cross-sectional imaging modalities, including spectral CT.
Main Results:
- Detailed description of EPS anatomy and its involvement in inflammatory, infectious, traumatic, neoplastic, and infiltrative disorders.
- Evaluation of the diagnostic capabilities of different imaging techniques for EPS lesions.
- Demonstration of how spectral CT aids in specific diagnosis through characteristic imaging features.
Conclusions:
- Accurate knowledge of EPS anatomy and imaging is essential for radiologists.
- Timely diagnosis of EPS pathologies impacts treatment strategies and malignancy staging.
- Advanced imaging techniques, particularly spectral CT, enhance diagnostic accuracy for EPS diseases.
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