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Related Experiment Video

Updated: Nov 8, 2025

Functional Calcium Imaging in Developing Cortical Networks

Functional Calcium Imaging in Developing Cortical Networks

Published on: October 22, 2011

Characterizing Cortex-Wide Dynamics with Wide-Field Calcium Imaging.

Chi Ren¹, Takaki Komiyama²

¹Neurobiology Section, Center for Neural Circuits and Behavior, Department of Neurosciences, and Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, California 92093.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|April 24, 2021

Summary

This summary is machine-generated.

Wide-field calcium imaging reveals brain-wide neural dynamics in behaving mice. This technique captures cortex-wide activity during complex cognitive tasks, advancing our understanding of neural circuits.

Keywords:

decision making large-scale cortical dynamics learning multimodal recordings sensorimotor integration wide-field calcium imaging

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Last Updated: Nov 8, 2025

Functional Calcium Imaging in Developing Cortical Networks

Functional Calcium Imaging in Developing Cortical Networks

Published on: October 22, 2011

In Vivo Wide-Field and Two-Photon Calcium Imaging from a Mouse Using a Large Cranial Window

In Vivo Wide-Field and Two-Photon Calcium Imaging from a Mouse Using a Large Cranial Window

Published on: August 4, 2022

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Published on: June 13, 2017

Area of Science:

Neuroscience
Systems Neuroscience
Computational Neuroscience

Background:

Brain function relies on coordinated activity across distributed regions.
Genetically encoded calcium indicators and wide-field imaging offer high signal-to-noise and spatiotemporal resolution.
This enables capturing cortex-wide neural dynamics in real-time in behaving animals.

Purpose of the Study:

To review recent advances in wide-field calcium imaging for studying brain dynamics.
To highlight the application of this technique in behaving mice.
To discuss technical considerations and future opportunities in large-scale circuit analysis.

Main Methods:

Wide-field calcium imaging.
Genetically encoded calcium indicators.
Behavioral paradigms in mice.

Main Results:

Uncovered cortical dynamics at unprecedented scales.
Revealed neural activity during sensorimotor integration and decision-making tasks.
Demonstrated the capability to capture moment-by-moment cortex-wide activity.

Conclusions:

Wide-field calcium imaging is a powerful tool for understanding large-scale brain circuit dynamics.
Recent advances have significantly enhanced our ability to study neural processes in behaving animals.
Future technical developments will further expand the scope of wide-field imaging in neuroscience.