Related Experiment Video
Updated: Nov 8, 2025

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
Published on: September 27, 2024
Bone Tissue Metabolism in Dynamics of Experimental Knee Osteoarthrosis Induced by Dexamethasone and Talcum
E V Gladkova1, Yu K Gladkova2, V Yu Ulyanov1
1Research Institute of Traumatology, Orthopedics and Neurosurgery, Saratov, Russia.
Abstract:
We studied remodeling of the bone tissue in the dynamics of experimental dexamethasoneand talcum-induced knee osteoarthrosis. Disturbed osteoclastogenesis accompanied by a decrease in the production of fibroblast growth factor-23 and elevation of serum osteoprotegerin and osteocalcin were observed at the early stages of the disease. During progression of degenerative and dystrophic processes in the joint tissues, an increase in sclerostin concentrations, a decrease in osteocalcin content, and changes in the force and direction of correlations between osteoblast processes and osteoclastogenesis as well as hierarchic distribution of the dominating mechanism of subchondral remodeling were revealed.
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling
Osteoclasts in Bone Remodeling

