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Updated: Nov 8, 2025

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
Published on: February 12, 2018
Redox imbalance in age-related ovarian dysfunction and perspectives for its prevention
F Timóteo-Ferreira1, D Abreu1, S Mendes1
1Intituto de Biologia Molecular e Celular (IBMC)/ Instituto de Inovação e Investigação em Saúde (I3S), Porto University, Portugal; Unit of Experimental Biology, Department of Biomedicine, Faculty of Medicine, Porto University, Portugal.
Abstract:
The age at which women have their first child is increasing. This change represents a major health problem to society because advanced maternal age is related with a decay in fertility and an increase in the incidence of a variety of pregnancy complications and offspring health issues. The ovary stands as the main contributor for female reproductive ageing because of the progressive age-related decrease in follicle number and oocyte quality. Loss of redox homeostasis and establishment of an ovarian oxidative microenvironment are seen as major underlying causes for such downfall and impairment of ovarian function. Thus, the use of antioxidants to preserve fertility became an important field of research. In this review, new insights on mechanisms underlying the establishment of oxidative stress and its repercussions on ovarian ageing are addressed, along with the current state of knowledge on antioxidant supplementation and its contribution for healthy ageing and extension of ovarian lifespan.
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