Stochastic morphological model of the rat lung

The laboratory rat is often used as a human surrogate in aerosol inhalation studies. Here we present a new stochastic model for the rat lung analogous to that for the human lung. Morphometric data on the tracheobronchial geometry of the rat lung provided by the Lovelace Inhalation Toxicology Research Institute were analyzed. The results of this statistical analysis reveal significant differences in diameters and branching angles between major and minor daughter tubes starting from the same bifurcation. As a consequence of the more monopodial airway branching in the rat lung compared to the more dichotomous structure of the human lung, we recommend classifying the rat lung airways by their diameters and not by generation numbers. The distributions of the geometric airway parameters and the correlations among them will be used for Monte Carlo deposition calculations.