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Updated: Nov 8, 2025

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
Published on: October 28, 2022
Opioids and Acute Kidney Injury
Mary Mallappallil1, Siddhartha Bajracharya2, Moro Salifu3
1Assistant Professor of Medicine, State University of New York at Downstate, Brooklyn, NY; Director of Service Nephrology, Kings County Hospital Center, Health and Hospitals Corporation, Brooklyn, NY.
Abstract:
Opioid use and misuse in the United States has been at epidemic proportions and is predicted to increase further in the setting of the Coronavirus disease 19 pandemic. Acute kidney injury is a condition associated with significant morbidity and increased mortality. We review the literature on the effect of opioids on kidney function and critically examine the association between opioid use and acute kidney injury and identify at-risk populations in whom opioids should be used with caution. We also discuss the role of biomarkers in elucidating this condition and propose preventive measures, novel therapeutic options, and research directions.
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