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Patch Testing During Immunosuppressive Therapy: A Systematic Review.

Asfandyar Mufti1, Justin D Lu2, Muskaan Sachdeva3

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This summary is machine-generated.

Patch testing accuracy in patients on immunosuppressants is not well understood. This review found many patients maintained positive patch test reactions, suggesting testing may still be viable in select cases.

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Patch testing is crucial for diagnosing allergic contact dermatitis.
  • Immunosuppressive therapy may affect patch test accuracy, but data is limited.

Purpose of the Study:

  • To systematically review patch testing results in patients undergoing immunosuppressive therapy.
  • To evaluate the impact of immunosuppressants on patch test accuracy.

Main Methods:

  • Systematic review of 16 studies involving 195 patients with dermatitis or psoriasis.
  • Analysis of patch test results from patients on various immunosuppressive medications.

Main Results:

  • 67.9% of dermatitis patients on dupilumab maintained previous positive patch test reactions.
  • Positive patch test results were observed with dupilumab, cyclosporine, low-dose prednisone, TNFα inhibitors, ustekinumab, and methotrexate.

Conclusions:

  • While ideally performed off immunosuppressants, patch testing may yield positive results in patients on certain therapies.
  • Clinicians should weigh the benefits of diagnosing allergic contact dermatitis against potential risks in patients on immunosuppression.