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Updated: Nov 8, 2025

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
Published on: April 29, 2011
Role of pulsatility on particle dispersion in expiratory flows
K Monroe1, Y Yao2, A Lattanzi2
1Department of Aerospace Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Abstract:
Expiratory events, such as coughs, are often pulsatile in nature and result in vortical flow structures that transport respiratory particles. In this work, direct numerical simulation (DNS) of turbulent pulsatile jets, coupled with Lagrangian particle tracking of micron-sized droplets, is performed to investigate the role of secondary and tertiary expulsions on particle dispersion and penetration. Fully developed turbulence obtained from DNS of a turbulent pipe flow is provided at the jet orifice. The volumetric flow rate at the orifice is modulated in time according to a damped sine wave, thereby allowing for control of the number of pulses, duration, and peak amplitude. Thermodynamic effects, such as evaporation and buoyancy, are neglected in order to isolate the role of pulsatility on particle dispersion. The resulting vortex structures are analyzed for single-, two-, and three-pulse jets. The evolution of the particle cloud is then compared to existing single-pulse models. Particle dispersion and penetration of the entire cloud are found to be hindered by increased pulsatility. However, the penetration of particles emanating from a secondary or tertiary expulsion is enhanced due to acceleration downstream by vortex structures.
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