Jove
Visualize
Contact Us

Related Concept Videos

Sleep-Wake Cycles01:24

Sleep-Wake Cycles

2.1K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
2.1K
Understanding Sleep01:11

Understanding Sleep

1.0K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.0K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

504
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
504
Narcolepsy01:07

Narcolepsy

276
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
276
Nightmares and Night Terrors01:18

Nightmares and Night Terrors

236
Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
Nightmares...
236
Sleepwalking and Sleep Talking01:17

Sleepwalking and Sleep Talking

457
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
457

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In memory of Lev Mukhametov.

Journal of sleep research·2021
Same author

Pannexin 1 Transgenic Mice: Human Diseases and Sleep-Wake Function Revision.

International journal of molecular sciences·2021
Same author

Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle.

Frontiers in cellular neuroscience·2017
Same author

Endothelial function is impaired in conduit arteries of pannexin1 knockout mice.

Biology direct·2014
Same author

Extracting evolutionary insights using bioinformatics.

International journal of genomics·2013
Same author

Some notes on the biography of Maria Manasseina.

Journal of the history of the neurosciences·2010
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Nov 8, 2025

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

10.1K

Total Wake: Natural, Pathological, and Experimental Limits to Sleep Reduction.

Yuri Panchin1,2, Vladimir M Kovalzon1,3

  • 1Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia.

Frontiers in Neuroscience
|April 26, 2021
PubMed
Summary

Reducing sleep duration may be possible without adverse effects. Research reviews evidence from sleep loss cases and genetic mutations, suggesting sleep might be a timing mechanism for inactivity rather than essential for survival.

Keywords:
Morvan syndromeREM sleepagrypniaevolutionnon-REM sleepsleep

More Related Videos

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.6K
Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

2.0K

Related Experiment Videos

Last Updated: Nov 8, 2025

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

10.1K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.6K
Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

2.0K

Area of Science:

  • Neuroscience
  • Chronobiology
  • Evolutionary Biology

Background:

  • Sleep occupies a significant portion of human life, prompting questions about its necessity and potential for reduction.
  • Conventional understanding posits sleep as vital for long-term survival, yet emerging evidence challenges this notion.

Purpose of the Study:

  • To review evidence challenging the necessity of prolonged sleep for survival.
  • To explore the potential for reducing sleep duration through biological or technological means.

Main Methods:

  • Analysis of clinical cases with complete or partial sleep loss.
  • Examination of human genetic mutations associated with short sleep phenotypes.
  • Review of supporting animal studies and evolutionary perspectives on sleep.

Main Results:

  • Limited but intriguing evidence suggests sleep may not be indispensable for long-term survival.
  • Clinical and genetic data indicate that reduced sleep is possible in some individuals.
  • Animal studies and evolutionary considerations provide further support for alternative sleep functions.

Conclusions:

  • Sleep's vital function, if any, remains unidentified, hindering the development of "sleep prostheses."
  • If sleep is an adaptive inactivity timer, its duration could potentially be reduced by modifying the sleep-generating system without negative consequences.