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Updated: Nov 8, 2025

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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Deciphering Multiple Sclerosis Progression.

Virginia Meca-Lallana1, Leticia Berenguer-Ruiz2, Joan Carreres-Polo3

  • 1Multiple Sclerosis Unit, Neurology Department, Fundación de Investigación Biomédica, Hospital Universitario de la Princesa, Madrid, Spain.

Frontiers in Neurology
|April 26, 2021
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) progression mechanisms are unclear, hindering early detection and treatment. This review explores MS progression, biomarkers, and therapies to prevent neurological disability.

Keywords:
MRImultiple sclerosisneurodegenerationneurofilamentprogressive multiple sclerosis

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Area of Science:

  • Neurology
  • Immunology
  • Neurodegeneration

Background:

  • Multiple sclerosis (MS) is a central nervous system inflammatory and degenerative disease.
  • Unknown environmental factors and genetic predispositions trigger MS.
  • Preventing neurological disability is a key goal in MS management.

Purpose of the Study:

  • To review current understanding of MS progression mechanisms.
  • To discuss strategies for measuring MS progression.
  • To explore biomarkers and therapeutic approaches for MS.

Main Methods:

  • Literature review of pathophysiological concepts in MS progression.
  • Analysis of measurement strategies for disability progression.
  • Examination of biomarkers and pharmacologic treatments for MS.

Main Results:

  • Pathophysiological mechanisms of MS progression are present from onset but poorly understood.
  • Current methods for detecting MS progression lack sensitivity and consensus.
  • The Expanded Disability Status Scale (EDSS) has limitations in assessing progression.

Conclusions:

  • Understanding MS progression is crucial for effective intervention.
  • Development of sensitive biomarkers and standardized criteria is needed for early detection.
  • Targeting early pathophysiological mechanisms may prevent long-term disability in MS.