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Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes

Xu-Lan Wang1, Wei Zhang2, Zhe Li2

  • 1Department of Nursing, Xian'yang Vocational and Technical College, Fengxi New Town United Avenue, Xi'an, Shaanxi 712000, P.R. China.

Molecular Medicine Reports
|April 26, 2021
PubMed

Insights

Circulating microparticles (MPs) link type 2 diabetes mellitus (T2DM) and acute coronary syndrome (ACS). MPs from T2DM and ACS patients impair vascular function, with combined T2DM and ACS showing the most significant effects.

Area of Science:

  • Cardiovascular Research
  • Endocrinology
  • Biomedical Science

Background:

  • Circulating microparticles (MPs) are implicated in both type 2 diabetes mellitus (T2DM) and acute coronary syndrome (ACS).
  • Understanding the role of MPs in the interplay between T2DM and ACS is crucial for developing targeted therapies.

Purpose of the Study:

  • To compare the content and functional impact of MPs from patients with ACS, T2DM, or both conditions on vascular health.
  • To elucidate the specific mechanisms by which MPs from these patient groups affect endothelial function.

Main Methods:

  • Quantification and functional assessment of MPs isolated from healthy subjects, patients with ACS, T2DM, and combined ACS-T2DM.
  • Incubation of rat thoracic tissue with MPs to evaluate endothelial-dependent vasodilatation, protein expression (caveolin-1, eNOS, Hsp90), and reactive oxygen/nitrogen species generation (NO, O2•−).

Main Results:

  • Elevated MP concentrations were observed in T2DM and ACS patients compared to healthy controls.
  • MPs from T2DM and ACS patients impaired endothelial vasodilatation, reduced NO and eNOS expression/Ser1177 phosphorylation, and increased T495 eNOS phosphorylation, caveolin-1 expression, and O2•− generation.
  • Combined ACS and T2DM exhibited potentiated negative effects on vascular function, indicating T2DM exacerbates MP-mediated vascular impairment in ACS.

Conclusions:

  • T2DM significantly contributes to increased MP levels and heightened vascular dysfunction in patients with ACS.
  • MPs represent a critical link between T2DM and ACS, offering potential therapeutic targets for managing these comorbid conditions.
Keywords:
acute coronary syndromecirculating microparticlesendothelial dysfunctionvascular injury

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