One-pot multi-step cascade protocols toward β-indolyl sulfoximidoyl amides via intermolecular trapping of an
Huahua Liu1, Li Wei1, Zhiyuan Chen1
1Key Laboratory of Functional Small Organic Molecules, Ministry of Education and Jiangxi Key Laboratory of Green Chemistry, College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. China. zchen@jxnu.edu.cn.
Abstract:
Various β-indolyl sulfoximidoyl amides were efficiently prepared from ortho-iodoanilines, propargyl bromides, 1 atm of CO, and substituted NH-sulfoximines, through a palladium-catalyzed indole annulation/carbonyl insertion/C-N bond formation cascade. Mostly good to high yields of the products were obtained through this multi-step, one-pot reaction protocol under very gentle reaction conditions. The obtained β-indolyl sulfoximidoyl amides could be converted into biologically interesting sulfoximine analogues that contain a tryptamine moiety.
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