Rapid access to difluoroalkyl phosphinimide heterocycles and their preliminary biological activities toward the
Xiaojuan Chen1,2, Muhammad Suleman2, Tiejun Zhao2
1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Abstract:
An efficient Ir-catalyzed multicomponent photoredox radical addition/C-H activation/annulation reaction for the synthesis of "CF2"-functionalized cyclic phosphinimides is reported. This strategy also enables the production of a library of phosphinimides with quaternary carbon centers by tolerating a range of radical species. Molecular docking simulations and experimental biological studies revealed that this type of CF2-substituted phosphinimide binds to the cathepsin D active site. Some hits that were related to this target site were found from preliminary biological screenings.
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