Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Periodic sharp waves in baclofen-induced encephalopathy.

J T Hormes1, E E Benarroch, M Rodriguez

  • 1Department of Neurology, Mayo Clinic, Rochester, Minn. 55905.

Archives of Neurology
|July 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accuracy of chat-based artificial intelligence for patient education on orthostatic hypotension.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2025
Same author

Ocular Motor Dysfunction due to Multiple Sclerosis.

Neuro-ophthalmology (Aeolus Press)·2017
Same author

Toward an optimal "antiplatelet" dose of aspirin: Preliminary observations.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Putative neuropathological interactions in MSA: focus in the rostral ventrolateral medulla.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2015
Same author

Midodrine efficacy in orthostatic hypotension.

Journal of general internal medicine·2014
Same author

Parabrachial nucleus involvement in multiple system atrophy.

Autonomic neuroscience : basic & clinical·2013

Baclofen can cause acute encephalopathy, a brain dysfunction, and abnormal EEG patterns. Symptoms improved rapidly after stopping the baclofen medication.

Area of Science:

  • Neurology
  • Clinical Pharmacology

Background:

  • Baclofen is a muscle relaxant commonly prescribed for spasticity.
  • Adverse neurological events associated with baclofen are not well-characterized.

Observation:

  • A 58-year-old woman developed acute encephalopathy.
  • Electroencephalogram (EEG) revealed periodic sharp wave patterns.

Findings:

  • The patient's symptoms emerged shortly after initiating baclofen therapy.
  • Discontinuation of baclofen led to prompt improvement in clinical and EEG abnormalities.

Implications:

  • This case highlights a potential adverse effect of baclofen, specifically reversible encephalopathy.
  • Clinicians should consider baclofen-induced neurotoxicity in patients presenting with encephalopathy and EEG changes.

Related Experiment Videos

  • Further research is warranted to understand the incidence and mechanisms of baclofen-related neurological adverse events.