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Natural Killer Cells: From Innate to Adaptive Features.
Adriana M Mujal1, Rebecca B Delconte1, Joseph C Sun1,2
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;
Annual Review of Immunology
|April 27, 2021
Summary
Natural killer (NK) cells are versatile immune cells. They exhibit both rapid innate responses and adaptive immune functions like memory, crucial for fighting infections and cancer.
Area of Science:
- Immunology
- Cell Biology
Background:
- Natural killer (NK) cells are key innate immune cells.
- NK cells are vital for host defense against pathogens and cancer.
Purpose of the Study:
- To review the dual role of NK cells in innate and adaptive immunity.
- To highlight the versatility of NK cells in human immune responses.
Main Methods:
- Literature review of NK cell research.
- Analysis of studies on NK cell effector functions and adaptive processes.
Main Results:
- NK cells possess rapid effector functions characteristic of innate immunity.
- NK cells demonstrate adaptive immune capabilities, including clonal expansion and memory formation.
- This adaptability is crucial for effective human immune responses.
Conclusions:
- NK cells bridge innate and adaptive immunity.
- Their versatile functions are critical for combating infections and cancer.
- Understanding NK cell plasticity enhances knowledge of human immunity.
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