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Episodic headache with spontaneous hypothermia reveal Shapiro's syndrome variant with effectiveness of clonidine
Mickael Aubignat1, Melissa Tir2,3, Pierre Krystkowiak2
1Department of Neurology and Center of Expertise in Parkinson's disease, University Hospital of Amiens, CHU Amiens-Picardie, 80 054 Cedex 1, Amiens, France. aubignat.mickael@chu-amiens.fr.
Background:
Episodic headache with spontaneous hypothermia constitute an uncommon association and is not well recognized in the International Classification of Headache Disorders (ICHD-3). Spontaneous periodic hypothermia, also called Shapiro's syndrome, is a rare disease characterized by hypothermia attacks associated or not with hyperhidrosis without any triggering factor.
Case Presentation:
We report a rare case of Shapiro's syndrome variantrevealed by episodes of headache with spontaneous hypothermia witheffectiveness of clonidine therapy in a 76-year-old Parkinson's disease woman.
Conclusions:
In the literature, apart from Shapiro's syndrome, headache withhypothermia seem to occur very rarely. In our case,these symptoms may be considered as a very rare non-motor fluctuation ofParkinson's disease.
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