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Updated: Nov 8, 2025

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
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RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing

Chaomei Xiang1, Karla K Frietze1, Yingtao Bi2

  • 1Weill Cornell Medical College, Department of Neurological Surgery, New York, New York, USA.

Molecular and Cellular Biology
|April 27, 2021
PubMed
Summary

RP58 (ZNF238) is a crucial transcription factor that maintains neuronal identity by repressing non-neuronal genes. Loss of RP58 is linked to brain development issues and glioma progression, highlighting its guardian role.

Keywords:
BTB/POZRP58ZBTB18cerebral cortexglioblastomagliomamicrocephalyneuronal differentiationneuronal identitytranscription factor, aging, neurodegenerative diseasestranscriptomics

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