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Updated: Nov 8, 2025

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Published on: June 2, 2014
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Cognitive dysfunction in a patient with migraine and APT1A2 mutation: a case report.
Pian Wang1, Yan-Rong Yang1, Hong-Bo Zhang1
1Department of Neurology, Chengdu Fifth Peoples' Hospital, No 33, Mashi Road, Wenjiang, Chengdu, Sichuan, People's Republic of China.
Summary
Hemiplegic migraine (HM) linked to the ATP1A2 gene mutation can cause lasting cognitive issues. This case highlights specific mathematical and spatial reasoning deficits in a young patient with HM.
Area of Science:
- Neurology
- Genetics
- Neuropsychology
Background:
- Hemiplegic migraine (HM) is a rare subtype of migraine with aura.
- The ATP1A2 gene mutation is associated with certain HM cases.
- Previous studies have described clinical HM manifestations but not detailed cognitive impacts.

