Related Experiment Video
Updated: Nov 8, 2025
07:47
The Slice Culture Method for Following Development of Tooth Germs In Explant Culture
Published on: November 13, 2013
14.4K
[Research progress in studies on tooth development based on diphyodont mammals].
1Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
Summary
Mice are poor models for human tooth development. Miniature pigs offer a superior diphyodont model for studying deciduous and permanent tooth development due to dental similarities.
Area of Science:
- Developmental Biology
- Comparative Anatomy
- Genetics
Background:
- Tooth development research traditionally relies on mice, which have significant morphological and developmental differences from humans.
- Mice possess only a single set of dentition, limiting their utility in studying permanent tooth development and replacement.
Purpose of the Study:
- To review current knowledge on primary and successional tooth development in miniature pigs.
- To evaluate miniature pigs as a model organism for diphyodont tooth development.
- To compare the suitability of various diphyodont mammal models.
Main Methods:
- Literature review of studies on diphyodont mammal tooth development.
- Comparative analysis of dentition in miniature pigs, ferrets, house shrews, and rabbits versus humans.
Main Results:
- Miniature pigs exhibit dentition morphology, number, and size closely resembling humans.
- Miniature pigs possess heterodont dentition (incisors, canines, premolars, molars), mirroring human dental structure.
- Other diphyodont models have limitations: ferrets (embryo access), house shrews (vestigial deciduous teeth), and rabbits (incomplete dentition).
Conclusions:
- Miniature pigs represent a valuable and accurate model for studying human diphyodont tooth development.
- The similarities in dentition make miniature pigs ideal for investigating molecular and cellular mechanisms of tooth replacement.
Related Concept Videos
01:15Teeth
1.1K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
1.1K
01:21Tooth Anatomy
1.5K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
1.5K