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Updated: Nov 8, 2025

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Water binding stabilizes stacked conformations of ferrocene containing sheet-like aromatic oligoamides
Ya-Zhou Liu1, Xiao Mu1, Cheih-Kai Chan2
1Institute of Condensed Matter and Nanosciences, Université catholique de Louvain, Place Louis Pasteur 1, Louvain-la-Neuve, 1348, Belgium. m.singleton@uclouvain.be.
Abstract:
While water clusters play an essential role in the stability of biological structures, their ability to stabilize synthetic oligomers is less understood. We have synthesized a heptameric sheet-like aromatic oligoamide foldamer with ferrocene as turn unit. It shows strong interactions with water in the solid state and in solution. The water binding limits the fluxional processes resulting from the flexible ferrocene unit, highlighting the importance of such interactions for conformational studies on this class of molecule.
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