Simultaneous Formation of a Fully Organic Triply Dynamic Combinatorial Library

Area of Science:

• Organic Chemistry
• Supramolecular Chemistry
• Materials Science

Background:

• Dynamic covalent chemistry (DCvC) enables the construction of adaptive molecular systems.
• Previous research has explored single and dual dynamic systems.
• The development of multi-dynamic systems remains a challenge.

Purpose of the Study:

• To report the simultaneous formation of doubly and triply dynamic libraries.
• To introduce a new type of fully organic triply dynamic molecular assembly.
• To explore the use of multiple reversible covalent linkages in molecular assembly.

Main Methods:

• Employing a combination of three distinct reversible covalent linkages: boronate ester transesterification, imine exchange, and disulfide exchange.
• Utilizing functionalized organic building blocks for library formation.
• Investigating the simultaneous nature of the exchange reactions.

Main Results:

• Successful simultaneous formation of both doubly and triply dynamic libraries.
• Demonstration of a new fully organic triply dynamic molecular assembly.
• Confirmation of the efficacy of combining boronate ester, imine, and disulfide exchange reactions.

Conclusions:

• The simultaneous formation of multi-dynamic libraries is achievable.
• Combining different reversible covalent bonds leads to complex dynamic molecular assemblies.
• This approach offers a new pathway for designing sophisticated organic materials.