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Overview of Secondary Neurulation
1Laboratoire de Biologie du développement, Sorbonne Université, Paris, France.
Journal of Korean Neurosurgical Society
|April 28, 2021
Summary
Secondary neurulation forms the caudal spinal cord. Research shows the tail bud has distinct territories, not undifferentiated cells, and defects can be open, challenging existing dogmas.
Area of Science:
- Developmental biology
- Embryology
- Neuroscience
Background:
- Secondary neurulation is crucial for caudal spinal cord formation in mammals and birds.
- The process has been studied since the 19th century, with established dogmas in medical literature.
- The tail bud, responsible for this process, was traditionally viewed as undifferentiated pluripotent cells.
Purpose of the Study:
- To re-evaluate the established dogmas surrounding secondary neurulation.
- To investigate the cellular composition and fate of the embryonic tail bud.
- To clarify the mechanisms of secondary neural tube formation and associated defects.
Main Methods:
- Experimental studies across different animal species.
- Analysis of embryonic development and tissue differentiation.
- Histological examination of neural tube formation.
Main Results:
- The tail bud is composed of distinct territories with predetermined fates, not undifferentiated pluripotent cells.
- The lumens of the neural tubes formed by primary and secondary neurulation are continuous.
- Defects in the internalization of superficial tissues can lead to open neural tube defects, contradicting the closed-defect dogma.
Conclusions:
- The traditional understanding of the tail bud's cellular nature requires revision.
- Secondary neurulation involves the internalization of superficial embryonic tissues.
- Neural tube defects arising from secondary neurulation can be open, not exclusively closed.
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