Stem cell-derived models of spinal neurulation
Camil Mirdass1,2,3,4, Martin Catala5, Mikaëlle Bocel1
1Université Paris Cité, CNRS, Institut Jacques Monod, F-75013 Paris, France.
Emerging Topics in Life Sciences
|December 13, 2023
Summary
Neurulation forms the neural tube, crucial for central nervous system development. Advanced stem cell models offer new ways to study this process and related birth defects.
Area of Science:
- Developmental biology
- Tissue engineering
- Stem cell research
Background:
- Neurulation is a fundamental process in embryonic development, forming the neural tube, the precursor to the central nervous system.
- Understanding neurulation is key to addressing neural tube defects, a significant category of birth defects.
- Complex morphogenetic events drive neural tube formation, involving multiple scales and tissues.
Conclusions:
- Stem cell-based in vitro models are powerful tools for investigating neurulation and neural tube defects.
- Further technical developments are needed to enhance the fidelity of these models.
- Continued research using these models promises deeper understanding of human developmental biology and pathology.
