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Updated: Nov 8, 2025
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Candida auris, an emerging pathogen - Challenge in the survival of microprimies
Gurujala Mahadeva Ramya1, Umamaheswari Balakrishnan1, Ashok Chandrasekaran1
1Department of Neonatology, Sri Ramachandra Institute of Higher Education & Research, Porur, Chennai, India.
Abstract:
Clinical profile of extreme preterm neonates and more so, of microprimies with birth weight < 800 g is not studied till now. Our article elaborates the profile of 5 microprimies with C.auris sepsis and review of literature. The mean gestational age and birth weight were 26 weeks ± 5 days and 709 ± 64 g respectively. Mortality was 80%. The organism was susceptible to micafungin, voriconazole but was resistant to fluconazole and amphotericin. Among the 5 babies, one had organ involvement in the form of cardiac vegetation. Early identification and optimal choice of drug are crucial for better survival in C.auris sepsis.
Insights
Clinical profiles of micro-preterm infants with Candida auris sepsis are poorly understood. This study highlights a high mortality rate and specific antifungal resistance patterns in these extremely vulnerable neonates.
Area of Science:
- Neonatology
- Infectious Diseases
- Mycology
Background:
- Clinical data on micro-preterm neonates (birth weight <800g) with Candida auris sepsis are scarce.
- Candida auris poses a significant threat to vulnerable infant populations, necessitating further research into its clinical impact.
Purpose of the Study:
- To elaborate on the clinical profile of 5 micro-preterm neonates with Candida auris sepsis.
- To review existing literature on Candida auris infections in extremely low birth weight infants.
Main Methods:
- Retrospective case series of 5 micro-preterm neonates diagnosed with Candida auris sepsis.
- Literature review of published cases of Candida auris in neonates.
Main Results:
- Mean gestational age was 26 weeks ± 5 days; mean birth weight was 709g ± 64g.
- Mortality rate was 80%.
- Candida auris demonstrated susceptibility to micafungin and voriconazole, but resistance to fluconazole and amphotericin B. One neonate developed cardiac vegetation.
Conclusions:
- Early identification and appropriate antifungal drug selection are critical for improving survival rates in neonates with Candida auris sepsis.
- The high mortality and specific antifungal resistance patterns underscore the challenges in managing these infections in micro-preterm infants.
