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Mitochondria targeted near-infrared chemodosimeter for upconversion luminescence bioimaging of hypoxia
Hui Yu1, Wanlu Sun1, Aliya Tiemuer1
1School of Engineering, China Pharmaceutical University, Nanjing, 211198, China. yiliu@cpu.edu.cn.
Chemical Communications (Cambridge, England)
|April 28, 2021
Abstract:
We report a mitochondria-targeted near-infrared probe (NRh-O) for frequency upconversion luminescence (FUCL) imaging of hypoxia. Under hypoxic conditions, NRh-O rapidly responds to release the FUCL product NRh (λex/em = 850/825 nm) with high sensitivity and selectivity in mitochondria. This highlights the potential application of a hypoxia-responsive probe in early clinical diagnosis.
