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Updated: Nov 7, 2025

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Axial Psoriatic Arthritis.

Dafna D Gladman1

  • 1Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, Ontario, 1E-410B, Canada. dafna.gladman@utoronto.ca.

Current Rheumatology Reports
|April 28, 2021
PubMed
Summary
This summary is machine-generated.

Axial psoriatic arthritis (axPsA) affects 40-50% of patients, but its unclear definition impacts prevalence estimates and trial design. Emerging evidence suggests axPsA is distinct from ankylosing spondylitis, and treatments for peripheral arthritis may benefit axPsA.

Keywords:
Axial diseaseDiagnosisPrognosisPsoriatic arthritisSpondylitis

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Area of Science:

  • Rheumatology
  • Immunology
  • Clinical Medicine

Background:

  • Axial psoriatic arthritis (axPsA) is a significant manifestation of psoriatic arthritis.
  • Understanding axPsA is crucial for developing targeted treatment strategies.

Purpose of the Study:

  • To review the current understanding of axPsA, including its prevalence, clinical characteristics, outcome measures, and recent therapeutic trials.
  • To highlight the distinct features of axPsA compared to other spondyloarthropathies.

Main Methods:

  • Literature review of prevalence studies, clinical feature analyses, and therapeutic trials in axPsA.
  • Synthesis of data on demographic, clinical, genetic, and therapeutic aspects of axPsA.

Main Results:

  • Estimated prevalence of axPsA ranges from 40-50%, though definitions remain inconsistent.
  • AxPsA exhibits distinct demographic, clinical, genetic, and therapeutic profiles compared to ankylosing spondylitis.
  • Recent trials indicate that therapies effective for peripheral psoriatic arthritis may also benefit axPsA.

Conclusions:

  • A clear definition of axPsA is needed to improve prevalence accuracy and facilitate robust clinical trial design.
  • AxPsA represents a unique disease domain within psoriatic arthritis.
  • Current therapeutic approaches for peripheral PsA show promise for managing axPsA.