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Genetic Polymorphisms Associated with Early Implant Failure: A Systematic Review
The International Journal of Oral & Maxillofacial Implants
|April 28, 2021
Summary
Genetic variations in MMP genes are linked to early dental implant failure. Understanding these polymorphisms is crucial for personalized dental medicine and improving implant success rates.
Area of Science:
- Genetics
- Biomaterials Science
- Oral and Maxillofacial Surgery
Background:
- Early dental implant failures can occur despite optimal surgical conditions and patient health.
- Intrinsic patient factors may influence osseointegration and implant success.
- Genetic polymorphisms are potential contributors to unexplained implant failures.
Purpose of the Study:
- To systematically review the association between genetic polymorphisms and early dental implant failure.
- To identify specific gene variations linked to osseointegration complications.
Main Methods:
- Systematic literature search of PubMed, ScienceDirect, and Scopus databases up to August 2019.
- Keywords: "Dental implant" AND "Polymorphism".
- PRISMA guidelines followed; risk of bias and heterogeneity assessed.
Main Results:
- Initial search yielded 225 articles; 10 met inclusion criteria after review.
- Five studies identified associations between specific polymorphisms and early implant failure.
- Polymorphisms studied include G-1607GG (MMP 1), C-799T (MMP 8), and -77 A>G (MMP 13).
Conclusions:
- MMP 1, MMP 8, and MMP 13 promoter polymorphisms alter transcriptional activity, affecting inflammation and matrix degradation.
- Establishing links between genetic polymorphisms and early implant loss supports precision medicine in dentistry.
- Further research can guide individualized treatment strategies to enhance dental implant outcomes.
