Related Experiment Video
Updated: Nov 7, 2025
Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging
Published on: June 14, 2021
Repeated 5-aminolevulinic Acid Instillations During Follow-up in Non-muscle-invasive Bladder Cancer: A Randomized
Eija Kelloniemi1, Riikka Järvinen2, Pekka Hellström3
1Department of Urology, Helsinki University Hospital, Helsinki, Finland; eija.kelloniemi@hus.fi.
Background/Aim:
Non-muscle invasive bladder carcinoma (NMIBC) is highly recurrent. We studied if 5-aminolevulinic acid (5-ALA) instillations before transurethral resection of bladder tumours (TURBT) and cystoscopy extend the time to recurrence during follow-up with NMIBC patients.
Patients And Methods:
A prospective multicenter study enrolled 328 NMIBC patients. All TURBTs and control cystoscopies during the one-year study period were done with or without 5-ALA instillations. The primary endpoint was time to recurrence. The secondary endpoints were time to recurrence after 7.5, 10.5, and 13.5 months and the number of patients with progressive disease.
Results:
The overall median follow-up time was 80.4 and 87.0 months for the control and study groups, respectively. There was no statistical difference in time to first recurrence between the two groups.
Conclusion:
We could not obtain significant differences between the control and 5-ALA groups in tumour recurrence among patients with NMIBC.
