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Intravenous Iron Replacement Therapy Improves Cardiovascular Outcomes in Hemodialysis Patients

Matteo Righini1, Vittorio Dalmastri2, Irene Capelli1

  • 1Department of Nephrology, Dialysis and Transplantation, Policlinico Sant'Orsola Malpighi, Bologna, Italy.

In Vivo (Athens, Greece)
|April 29, 2021
PubMed

Insights

Intravenous ferric carboxymaltose (FCM) in hemodialysis patients with iron deficiency reduced cardiovascular events and erythropoiesis-stimulating agent (ESA) doses. This treatment improved iron levels and patient outcomes.

Area of Science:

  • Nephrology
  • Cardiology
  • Hematology

Background:

  • Cardiovascular disease (CVD) is the leading cause of mortality in hemodialysis (HD) patients.
  • Iron deficiency is common in HD patients and linked to adverse outcomes.
  • Intravenous iron administration is a standard treatment for iron deficiency in HD.

Purpose of the Study:

  • To investigate the impact of intravenous ferric carboxymaltose (FCM) on cardiovascular events in iron-deficient hemodialysis patients.
  • To assess changes in clinical, echocardiographic, and laboratory parameters following FCM therapy.

Main Methods:

  • Retrospective study of hemodialysis patients from September 2016 to December 2019.
  • Comparison between patients receiving FCM (FCM group) and those not receiving FCM (control group).
  • Analysis of clinical, echocardiographic, and laboratory data at baseline (t0) and after one year (t1).

Main Results:

  • 53 patients in the FCM group and 19 in the control group were identified.
  • The FCM group showed a significant reduction in erythropoiesis-stimulating agent (ESA) doses (p<0.001).
  • A significant decrease in cardiovascular events was observed in the FCM group (p<0.01), with no changes in echocardiographic parameters.

Conclusions:

  • Ferric carboxymaltose (FCM) therapy in iron-deficient hemodialysis patients leads to improved iron status (transferrin saturation and ferritin).
  • FCM treatment is associated with a reduction in coronary artery and overall cardiovascular events.
  • Patients receiving FCM could reduce their required doses of erythropoiesis-stimulating agents (ESA).
Abstract

Keywords:
Anaemiacardiovascular diseaseechocardiographyhaemodialysisiron

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