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Association between Homocysteine Levels and Psoriasis: A Meta-Analysis

Jung Eun Kim1, Ho Jung Lee1, Jong Suk Lee1

  • 1Department of Dermatology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

Annals of Dermatology
|April 29, 2021
PubMed

Insights

Psoriasis patients have higher homocysteine (Hcy) levels, a marker of cardiovascular risk. This elevation is particularly significant in individuals with severe psoriasis (PASI >10).

Area of Science:

  • Dermatology
  • Cardiovascular Medicine
  • Clinical Chemistry

Background:

  • Psoriasis is a chronic inflammatory disease linked to increased cardiovascular disease risk.
  • Elevated homocysteine (Hcy) levels are recognized biomarkers for cardiovascular risk.
  • Previous studies on the association between psoriasis and Hcy levels have yielded inconclusive results.

Purpose of the Study:

  • To conduct a systematic literature review and meta-analysis to clarify the relationship between psoriasis and homocysteine levels.
  • To investigate whether psoriasis is associated with altered plasma homocysteine concentrations.

Main Methods:

  • A comprehensive search of five major scientific databases (MEDLINE, Embase, Cochrane Library, Scopus, Web of Science) was performed.
  • 16 studies directly measuring plasma homocysteine levels in psoriasis patients were identified from 307 publications.
  • A meta-analysis was conducted on data from 2,091 subjects.

Main Results:

  • Psoriasis patients exhibited significantly higher homocysteine levels compared to healthy controls (WMD, 3.30; 95% CI, 1.58–5.02).
  • Subgroup analysis indicated that patients with higher Psoriasis Area and Severity Index (PASI) scores (PASI >10) showed significantly elevated homocysteine levels (WMD, 4.17; 95% CI, 1.18–7.16).
  • Patients with lower PASI scores (PASI ≤10) did not demonstrate a significant difference in homocysteine levels compared to controls (WMD, 0.76; 95% CI, -1.84–3.35).

Conclusions:

  • This meta-analysis confirms that psoriasis patients, especially those with severe disease (PASI >10), have significantly elevated homocysteine levels.
  • The findings suggest a potential link between psoriasis severity and homocysteine levels.
  • Further research is warranted to elucidate the precise association between homocysteine and psoriasis severity.
Abstract

Keywords:
HomocysteineMeta-analysisPsoriasis

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