NIR-absorbing Prussian blue nanoparticles for transarterial infusion photothermal therapy of VX2 tumors implanted in rabbits
Huajin Pang1, Chen Tian, Genghan He
1Division of Vascular and Interventional Radiology, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Abstract:
Nanomaterial-related photothermal therapy has been intensively investigated for treatment of hepatocellular carcinoma (HCC). However, owing to the low specificity to tumors and easy excretion from the systemic circulation, the low dose of photoactive nanomaterials in solid tumors severely hinders the photothermal therapy applications for HCC. Herein, an innovative strategy for transarterial infusion photothermal therapy (TAIPPT) of VX2 tumors implanted in rabbits is reported. NIR-absorbing Prussian blue nanoparticles were prepared by microemulsion methods, which demonstrate excellent photothermal therapy capacity and satisfactory biocompatibility. Prussian blue nanoparticles are transarterially infused into VX2 tumors and irradiated for photothermal therapy. TAIPPT achieves fast and efficient delivery of nanoparticles into tumors and complete ablation by one-time transarterial infusion treatment. Furthermore, TAIPPT could activate the immune cells in rabbits and inhibit distant tumors. Our findings describe a promising strategy for tumor eradication and may benefit future clinical HCC patients.
Insights
Transarterial infusion photothermal therapy (TAIPPT) effectively delivers Prussian blue nanoparticles to hepatocellular carcinoma (HCC) tumors. This novel approach ensures complete tumor ablation and stimulates an anti-tumor immune response, offering a promising treatment for HCC.
Area of Science:
- Biomedical Engineering
- Nanomedicine
- Oncology
Background:
- Photothermal therapy (PTT) using nanomaterials is explored for hepatocellular carcinoma (HCC).
- Low tumor specificity and rapid clearance of nanomaterials limit PTT efficacy in solid tumors.
- Developing targeted delivery methods is crucial for enhancing PTT for HCC treatment.
Purpose of the Study:
- To develop and evaluate an innovative transarterial infusion photothermal therapy (TAIPPT) strategy for HCC.
- To assess the efficacy of Prussian blue nanoparticles delivered via TAIPPT for VX2 tumor ablation in rabbits.
- To investigate the potential of TAIPPT to induce systemic anti-tumor immunity.
Main Methods:
- Synthesized NIR-absorbing Prussian blue nanoparticles using microemulsion methods.
- Administered nanoparticles via transarterial infusion directly into VX2 tumors in rabbits.
- Irradiated tumors with near-infrared (NIR) light to induce hyperthermia for photothermal therapy.
Main Results:
- TAIPPT achieved efficient and localized delivery of Prussian blue nanoparticles to tumors.
- A single TAIPPT treatment resulted in complete ablation of VX2 tumors.
- The treatment demonstrated satisfactory biocompatibility and activated immune cells, inhibiting distant tumors.
Conclusions:
- TAIPPT is a highly effective strategy for targeted delivery and ablation of HCC tumors.
- This method overcomes limitations of traditional PTT by ensuring high nanoparticle dosage at the tumor site.
- TAIPPT shows potential for enhancing cancer immunotherapy and could benefit future clinical applications for HCC patients.
