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Related Experiment Video

Updated: Nov 7, 2025

Induction and Analysis of Epithelial to Mesenchymal Transition
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Defining epithelial-mesenchymal transitions in animal development.

Guojun Sheng1

  • 1International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.

Development (Cambridge, England)
|April 29, 2021
PubMed
Summary

Epithelial-mesenchymal transition (EMT) is crucial in development and cancer. This review summarizes EMT research, models, and criteria for identifying EMT-related morphogenetic events.

Keywords:
Cancer metastasisDevelopmental modelsEMTEpitheliumMETMesenchyme

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Cancer Research

Background:

  • Epithelial-mesenchymal transition (EMT) is a fundamental biological process.
  • EMT research has expanded significantly, particularly in cancer studies.
  • EMT plays roles in both physiological development and pathological conditions like cancer.

Purpose of the Study:

  • To summarize the current state of epithelial-mesenchymal transition (EMT) research.
  • To provide an overview of EMT models used in developmental studies.
  • To establish criteria for distinguishing EMT-related phenomena.

Main Methods:

  • Literature review of EMT research and models.
  • Analysis of dynamic epithelialization and de-epithelialization events.
  • Development of criteria for EMT classification.

Main Results:

  • EMT is a widely applied concept in morphogenetic studies.
  • Cancer research has driven recent growth in the EMT field.
  • Dynamic epithelialization/de-epithelialization are key developmental events.

Conclusions:

  • EMT research is rapidly evolving with implications for cancer therapy.
  • Broader consideration of epithelialization/de-epithelialization offers new perspectives on EMT.
  • Clear criteria are needed to define EMT-related morphogenetic phenomena.