Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation01:37

Neural Regulation

41.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
41.1K
Neuromuscular Junction And Blockade01:29

Neuromuscular Junction And Blockade

4.0K
The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
4.0K
Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

3.1K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
3.1K
The Neuromuscular Junction01:19

The Neuromuscular Junction

15.7K
The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
15.7K
Motor Unit Stimulation01:20

Motor Unit Stimulation

3.0K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
3.0K
Nondepolarizing (Competitive) Neuromuscular Blockers: Mechanism of Action01:17

Nondepolarizing (Competitive) Neuromuscular Blockers: Mechanism of Action

2.4K
Nondepolarizing neuromuscular blockers induce paralysis by competitively blocking nicotinic acetylcholine receptors at the muscle end plate. Examples include pancuronium, mivacurium, vecuronium, and rocuronium. These quaternary ammonium derivatives are administered intravenously, are poorly absorbed, and are excreted via the kidneys.
Competitive antagonists prevent acetylcholine from binding to its receptor, inhibiting membrane depolarization. Without conformational changes or intrinsic...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

5-year longitudinal follow-up of patients treated for chronic mechanical low back pain using restorative neurostimulation.

Regional anesthesia and pain medicine·2025
Same author

Two-Year Outcomes Using Fast-Acting, Sub-Perception Therapy for Spinal Cord Stimulation: A European, Real-World, Multicenter Experience.

Journal of clinical medicine·2024
Same author

Towards net-zero operating in neurosurgery.

British journal of neurosurgery·2024
Same author

Real-world outcomes of single-stage spinal cord stimulation in chronic pain patients: A multicentre, European case series.

Interventional pain medicine·2024
Same author

Spinal Cord Stimulation Improves Quality of Life for Patients With Chronic Pain-Data From the UK and Ireland National Neuromodulation Registry.

Neuromodulation : journal of the International Neuromodulation Society·2024
Same author

Restorative neurostimulation for chronic mechanical low back pain - Three year results from the United Kingdom post market clinical follow-up registry.

British journal of pain·2023
Same journal

Non-Antibiotic Prophylaxis for Recurrent Urinary Tract Infection: A Narrative Review & Clinical Guide for Primary and Hospital Care.

British journal of hospital medicine (London, England : 2005)·2026
Same journal

Diagnostic Utility of Eosinophil and Platelet in Newborns With Food Protein-Induced Allergic Proctocolitis: A Retrospective Study.

British journal of hospital medicine (London, England : 2005)·2026
Same journal

Maternal Obesity and Neonatal Cardiac Remodeling Among Cesarean Deliveries: The Predictive Role of Maternal Lipid Profiles and Pre-Pregnancy BMI Based on Echocardiographic Assessment.

British journal of hospital medicine (London, England : 2005)·2026
Same journal

Thinking Beyond the Hip: A Clinico-Radiological Approach to Atypical Paediatric Hip Pain for the Generalist.

British journal of hospital medicine (London, England : 2005)·2026
Same journal

The Association Between Glycemic Disorders and Acute Coronary Syndrome: Plaque Vulnerability in Perimenopausal and Post-Menopausal Women With Diabetes.

British journal of hospital medicine (London, England : 2005)·2026
Same journal

Effects of Left Bundle Branch Pacing and Right Ventricular Pacing on Blood Pressure and Cardiac Function in Patients With Bradyarrhythmia Complicated With Hypertension.

British journal of hospital medicine (London, England : 2005)·2026
See all related articles

Related Experiment Video

Updated: Nov 7, 2025

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

13.3K

Neuromodulation.

Sarah Love-Jones1

  • 1Department of Anaesthesia, Southmead Hospital, North Bristol NHS Trust, UK.

British Journal of Hospital Medicine (London, England : 2005)
|April 29, 2021
PubMed
Summary
This summary is machine-generated.

Spinal cord stimulation (SCS) is a key neuromodulation treatment for chronic neuropathic pain. This article explains SCS therapy, its process, and patient suitability for this advanced pain management option.

Keywords:
NeuromodulationNeuropathic painSpinal cord stimulation

More Related Videos

Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays
04:00

Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays

Published on: May 3, 2024

1.6K
Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation
04:59

Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation

Published on: January 19, 2024

3.0K

Related Experiment Videos

Last Updated: Nov 7, 2025

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

13.3K
Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays
04:00

Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays

Published on: May 3, 2024

1.6K
Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation
04:59

Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation

Published on: January 19, 2024

3.0K

Area of Science:

  • Neurology
  • Pain Management
  • Neurosurgery

Background:

  • Neuromodulation offers advanced treatment options for chronic pain.
  • Spinal cord stimulation (SCS) is a primary neuromodulation therapy.
  • Neuropathic pain conditions often require specialized interventions.

Purpose of the Study:

  • To describe the principles of neuromodulation.
  • To detail the process of spinal cord stimulation therapy.
  • To clarify patient selection criteria for SCS.

Main Methods:

  • Literature review on neuromodulation techniques.
  • Explanation of the SCS procedure.
  • Discussion of patient assessment for SCS candidacy.

Main Results:

  • Neuromodulation involves modulating nerve activity.
  • SCS therapy delivers electrical impulses to the spinal cord.
  • Patient suitability depends on pain type, history, and psychological factors.

Conclusions:

  • Spinal cord stimulation is an established therapy for specific chronic neuropathic pain.
  • Understanding the SCS process and patient selection is crucial for successful outcomes.
  • This article provides a guide for clinicians considering SCS referrals.