Related Experiment Video
Updated: Nov 7, 2025
10:19
A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
14.7K
Vulvovaginal Involvement in Pediatric Stevens-Johnson Syndrome: A Case Series
Max Holtz1, Frances Grimstad2, Jeannette Higgins3
1Childrens' Mercy Hospital and University of Missouri Kansas City, Kansas City, Missouri, and Department of Obstetrics and Gynecology, University of Missouri Kansas City, Kansas City, Missouri; Department of Women's Health, Dell Medical School, The University of Texas, Austin, Texas.
Journal of Pediatric and Adolescent Gynecology
|April 29, 2021
Summary
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe skin reactions. Vulvovaginal involvement can occur, but prompt management may prevent lasting damage.
Area of Science:
- Dermatology
- Toxicology
- Gynecology
Background:
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe, life-threatening mucocutaneous hypersensitivity reactions.
- These reactions are characterized by prodromal symptoms followed by widespread rash due to keratinocyte apoptosis and epidermal detachment.
Observation:
- Three adolescent patients presented with SJS/TEN involving the vulvovaginal area after starting lamotrigine, trimethoprim-sulfamethoxazole, and phenobarbital.
- Treatment included intravenous immunoglobulin, steroids, etanercept in one case, topical emollients, and meticulous perineal hygiene.
Findings:
- Vulvovaginal SJS/TEN can lead to permanent architectural changes if not managed promptly.
- Early interventions such as medication withdrawal, systemic corticosteroids, intravenous immunoglobulin, and supportive care are crucial.
- Vaginoscopy confirmed no permanent sequelae in one patient, highlighting the potential for full recovery.
Implications:
- Prompt diagnosis and management of vulvovaginal SJS/TEN are essential to prevent long-term complications.
- A multidisciplinary approach involving dermatology, gynecology, and supportive care is recommended.
- Further research into optimal management strategies for SJS/TEN with mucosal involvement is warranted.
Related Concept Videos
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
95
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
95
01:26Sexually Transmitted Infections
531
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
531
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
56
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
56
01:25Urinary Tract Infection II: Pathophysiology
256
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
256
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
290
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
290
01:26Factors Affecting the Risk of Infection
13.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.0K