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Updated: Nov 7, 2025

Investigating Migraine-Like Behavior Using Light Aversion in Mice
Published on: August 11, 2021
CGRP Receptor Antagonists and 5-HT1F Receptor Agonist in the Treatment of Migraine
Matilde Capi1, Valerio De Angelis2, Donatella De Bernardini1
1Laboratory of Clinical Biochemistry, Mass Spectrometry Unit, Sant'Andrea University Hospital, 00185 Rome, Italy.
Abstract:
Discovering that calcitonin-related peptide (CGRP) plays a key role in the complex pathophysiology of migraine has allowed us to make great strides in the development of new approaches for acute and preventive treatment. This evidence has led to the development of small molecules antagonist molecules of the CGRP receptor ("gepants") and of a new class of medications called "Ditans". This review presents the data from clinical trials reporting the efficacy, safety, and tolerability of the new drugs used in the treatment of migraines. Evidences show that therapeutic approaches targeted to CGRP have the potential to transform the clinical management of migraine, even though its appropriate place has yet to be determined with accuracy.
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