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Low Serum Uric Acid Predicts Risk of a Composite Disease Endpoint
Fatma Özpamuk-Karadeniz1, Yusuf Karadeniz2, Adnan Kaya3
1Departments of Cardiology, Special Büyükşehir Hospital, 42010 Konya, Turkey.
Medicina (Kaunas, Lithuania)
|April 30, 2021
Summary
Low serum uric acid (SUA) levels predict adverse outcomes, particularly non-fatal events in men. However, high SUA may indicate risks for diabetic women, suggesting complex associations with health.
Area of Science:
- Cardiovascular Health
- Metabolic Syndrome
- Clinical Chemistry
Background:
- Both high (hyperuricemia) and low (hypouricemia) serum uric acid (SUA) levels are linked to increased mortality.
- The predictive value of low SUA for overall mortality and composite endpoints requires further investigation.
Purpose of the Study:
- To assess the predictive value of low serum uric acid (SUA) levels on the risk of overall mortality or a composite endpoint of death and nonfatal events.
- To evaluate the association of sex-specific SUA tertiles with defined outcomes in community-based adults.
Main Methods:
- Prospective cohort study of 1013 middle-aged adults without pre-existing coronary heart disease or uncontrolled diabetes.
- Logistic regression analysis was used to evaluate sex-specific SUA tertiles and dichotomized SUA levels against outcomes.
- Analyses were stratified by gender and presence of type-2 diabetes.
Main Results:
- Low SUA (<5.1 and <4.1 mg/dL) significantly predicted non-fatal events in the overall sample and in men (RR 1.51).
- The composite endpoint risk tended to increase with low SUA in the whole sample (RR 1.38).
- Adverse outcomes in diabetic women were associated with intermediate and high SUA tertiles.
Conclusions:
- An inverse association between SUA and adverse outcomes, particularly in men, suggests a role for uric acid in autoimmune processes.
- The positive association of SUA with adverse outcomes in diabetic women may be linked to high-density lipoprotein dysfunction.
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