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Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
Shigeki Ito1, Tsuyoshi Sato1, Takahiro Maeta1
1Division of Hematology & Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine, Yahaba 028-3695, Japan.
Abstract:
The C-X-C chemokine receptor type 4 (CXCR4) is a pleiotropic chemokine receptor that is expressed in not only normal hematopoietic cells but also multiple myeloma cells. Its ligand, stromal cell-derived factor 1α (SDF-1α) is produced in the bone marrow microenvironment. The SDF-1α/CXCR4 axis plays a pivotal role in the major physiological processes associated with tumor proliferation, survival, invasion, dissemination, and drug resistance in myeloma cells. This review summarizes the pleiotropic role of the SDF-1α/CXCR4 axis in multiple myeloma and discusses the future perspective in the SDF-1α/CXCR4 axis-targeted therapies in multiple myeloma.
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