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Dimensions Used in Instruments for QALY Calculation: A Systematic Review.
Moustapha Touré1,2, Christian R C Kouakou1,2, Thomas G Poder2,3
1Department of Economics, Business School, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
This systematic review examines instruments for calculating quality-adjusted life-years (QALYs), finding specific instruments are often developed due to generic tool limitations. Methods for selecting and validating dimensions and utility scoring models are detailed.
Area of Science:
- Health Economics
- Health Services Research
- Psychometrics
Background:
- Economic assessment is crucial for healthcare decision-making.
- Quality-adjusted life-year (QALY) integrates mortality and morbidity for cost-utility analysis.
- Health-related quality of life (HRQoL) instruments are vital for QALY calculations.
Purpose of the Study:
- To systematically review instruments used for QALY calculation.
- To analyze instrument characteristics, development, and validation methods.
- To inform the selection and adaptation of appropriate HRQoL instruments.
Main Methods:
- Systematic literature review of 46 studies up to June 2020.
- Searches conducted in Medline EBSCO, Scopus, ScienceDirect, and PubMed.
- Focus on instrument type (generic vs. specific), dimensions, elicitation methods, and validation.
Main Results:
- Specific instruments are frequently developed due to generic instrument limitations.
- Item response theory, Rasch analysis, and literature review guide dimension selection.
- Time trade-off and visual analogue scale are common elicitation methods.
- Random effects regression models are often used for utility score determination.
Conclusions:
- Understanding instrument development and validation is key for selecting appropriate QALY tools.
- Specific instruments offer tailored solutions when generic measures are inadequate.
- Standardized methods for dimension selection and validation enhance QALY instrument reliability.
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