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Apoptosis Disorder, a Key Pathogenesis of HCMV-Related Diseases

Zhongjie Yu1, Yashuo Wang2, Lili Liu3

  • 1Department of Special Medicine, School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao 266000, China.

International Journal of Molecular Sciences
|April 30, 2021
PubMed

Insights

Human cytomegalovirus (HCMV) disrupts host cell apoptosis, contributing to various diseases. This review summarizes HCMV

Area of Science:

  • Virology
  • Immunology
  • Cell Biology

Background:

  • Human cytomegalovirus (HCMV) is a ubiquitous β-herpesvirus affecting over 90% of the global population.
  • HCMV infection is linked to numerous diseases, often by interfering with host cell apoptosis.
  • Disordered apoptosis is a critical factor in the development of many pathologies.

Purpose of the Study:

  • To systematically review the role of apoptosis in HCMV-related diseases.
  • To elucidate the molecular mechanisms by which HCMV infection induces apoptosis.
  • To identify potential therapeutic strategies targeting apoptosis for HCMV treatment.

Main Methods:

  • Literature review of studies on HCMV infection and apoptosis.
  • Analysis of molecular pathways involved in HCMV-induced apoptosis.
  • Synthesis of current knowledge on HCMV-related diseases and apoptosis.

Main Results:

  • HCMV infection significantly impacts host cell apoptosis.
  • Specific molecular mechanisms underlying HCMV-induced apoptosis are identified.
  • Apoptosis dysregulation is a common feature in HCMV-associated pathologies.

Conclusions:

  • Apoptosis plays a crucial role in the pathogenesis of HCMV-related diseases.
  • Understanding HCMV's manipulation of apoptosis offers therapeutic targets.
  • Regulating apoptosis presents a promising strategy for novel HCMV treatments.
Keywords:
HCMVapoptosismolecular mechanismtarget therapy

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