Related Experiment Video
Updated: Nov 7, 2025
09:55
Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
Published on: October 25, 2024
1.2K
Decoy Technology as a Promising Therapeutic Tool for Atherosclerosis
Maryam Mahjoubin-Tehran1, Yong Teng2, Amin Jalili1
1Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
International Journal of Molecular Sciences
|April 30, 2021
Summary
Decoy-based therapies offer a novel approach to treat atherosclerosis, a prevalent inflammatory cardiovascular disease. These candidates inhibit pathways promoting atherosclerosis, addressing limitations of current treatments.
Area of Science:
- Cardiovascular Medicine
- Inflammatory Diseases
- Pharmacology
Background:
- Atherosclerosis is a leading cause of death, characterized by arterial wall lesions and inflammation.
- Current therapies like statins are insufficient for some patients with familial hypercholesterolemia due to efficacy or side effects.
- Significant residual risk persists even with controlled LDL-C levels, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review the potential of decoy-based drug candidates for treating atherosclerosis.
- To evaluate in vitro and in vivo findings related to decoy therapies.
Main Methods:
- Literature review of in vitro and in vivo studies.
- Analysis of decoy mechanisms targeting regulatory pathways in atherosclerosis.
Main Results:
- Decoy-based drug candidates show promise in inhibiting pro-atherosclerotic regulatory pathways.
- Evidence from in vitro and in vivo studies supports the therapeutic potential of decoys.
Conclusions:
- Decoy-based therapies represent a promising new avenue for managing atherosclerosis.
- Further research into decoys could lead to more effective treatments with fewer side effects for cardiovascular disease.
Related Concept Videos
01:26Atherosclerosis III: Management
91
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
91
01:30Atherosclerosis I: Introduction
315
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
315
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
133
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
133
01:23Atherosclerosis IV: Nursing Management
116
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
116
01:27Coronary Artery Disease V: Interprofessional Care
93
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
93
01:30Acute Coronary Syndrome III: Diagnostic Studies
67
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
67