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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
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Phosphate, Microbiota and CKD.

Chiara Favero1, Sol Carriazo1,2, Leticia Cuarental1,2

  • 1Department of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Av Reyes Católicos 2, 28040 Madrid, Spain.

Nutrients
|April 30, 2021
PubMed
Summary
This summary is machine-generated.

Phosphate overload in chronic kidney disease (CKD) affects bone health. The gut microbiota influences mineral and bone disorders (CKD-MBD) by producing compounds like butyrate, impacting parathyroid hormone

Keywords:
PTHchronic kidney diseasemicrobiotaphosphatephosphate bindershort chain fatty aciduremic toxins

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Area of Science:

  • Nephrology
  • Microbiology
  • Endocrinology

Background:

  • Phosphate is a critical uremic toxin linked to poor outcomes in chronic kidney disease (CKD).
  • Reduced kidney phosphate excretion in CKD leads to CKD-mineral and bone disorder (CKD-MBD), often managed with diet and binders.
  • Emerging evidence highlights the gut microbiota's role in CKD-MBD.

Purpose of the Study:

  • To review the intricate relationship between phosphate metabolism, gut microbiota, and CKD-MBD.
  • To explore microbial bioactive compounds relevant to CKD.
  • To discuss the therapeutic potential of microbiota modulation for CKD-MBD.

Main Methods:

  • Literature review of current knowledge on phosphate, microbiota, and CKD-MBD.
  • Analysis of studies investigating the impact of diet and phosphate binders on gut microbiota.
  • Examination of research on microbiota's role in parathyroid hormone (PTH)-mediated bone changes.

Main Results:

  • Gut microbiota composition, specifically segmented filamentous bacteria, influences PTH-induced bone loss.
  • Microbiota is essential for PTH's effects on bone formation and mass, mediated by butyrate production.
  • Dietary phosphate and binders significantly alter gut microbiota.

Conclusions:

  • The gut microbiota plays a crucial role in regulating bone metabolism in CKD.
  • Microbiota-derived compounds like butyrate are key mediators in CKD-MBD.
  • Targeting the gut microbiota offers a promising therapeutic avenue for managing CKD-MBD.