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Genomic Instability in Multiple Myeloma: A "Non-Coding RNA" Perspective
Elisa Taiana1,2, Maria Eugenia Gallo Cantafio3, Vanessa Katia Favasuli1,2
1Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy.
Cancers
|April 30, 2021
Summary
Genomic instability (GI) drives multiple myeloma (MM) progression. This review explores how non-coding RNAs impact GI, offering potential new therapeutic targets for this hematological malignancy.
Area of Science:
- Hematological Malignancy Research
- Cancer Genomics
- Molecular Biology
Background:
- Multiple myeloma (MM) is a cancer of plasma cells, often linked to genomic instability (GI).
- GI, the accumulation of genetic alterations, is present even in pre-malignant stages like MGUS and SMM.
- Replication stress and DNA repair pathway issues are known contributors to GI in MM.
Purpose of the Study:
- To review the molecular mechanisms underlying genomic instability in multiple myeloma.
- To highlight the role of non-coding RNAs in MM pathogenesis and GI.
- To discuss non-coding RNAs as potential therapeutic targets for tackling GI in MM.
Main Methods:
- Literature review of studies on genomic instability in multiple myeloma.
- Analysis of research on non-coding RNA dysregulation in MM.
- Synthesis of information on molecular determinants of GI and therapeutic strategies.
Main Results:
- Genomic instability is a key feature in the progression of multiple myeloma.
- Non-coding RNAs are significantly dysregulated in MM and influence GI pathways.
- These non-coding RNAs represent a novel avenue for therapeutic intervention against GI.
Conclusions:
- Understanding the molecular basis of GI in MM is crucial for effective treatment.
- Non-coding RNAs play a significant role in the development and progression of MM by affecting GI.
- Targeting non-coding RNAs offers a promising strategy to combat genomic instability in multiple myeloma.
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