Recent Advances in CRP Biosensor Based on Electrical, Electrochemical and Optical Methods.

Area of Science:

• Biomaterials Science
• Nanotechnology
• Clinical Diagnostics

Background:

• C-reactive protein (CRP) is a key inflammatory marker, crucial for diagnosing acute and chronic inflammatory/infectious diseases.
• Current CRP assays, primarily ELISA, offer high sensitivity but suffer from complex procedures, long analysis times, and require specialized personnel.
• Advancements in diagnostic techniques enable more precise CRP measurement, expanding its role beyond traditional biomarker applications.

Purpose of the Study:

• To review recent progress in developing novel C-reactive protein (CRP) biosensors.
• To explore the application of nanobiotechnology in creating advanced CRP detection platforms.
• To highlight the advantages of nanobio hybrid materials in CRP biosensor development.

Main Methods:

• Review of recent advancements in electrochemical, electricity, and spectroscopy-based CRP biosensors.
• Integration of biomaterials and nanomaterials to create hybrid biosensor platforms.
• Focus on nanobiotechnology-enabled diagnostic tools for CRP detection.

Main Results:

• Nanobio hybrid materials significantly enhance CRP biosensor performance.
• New biosensors enable quicker and more accurate CRP quantification.
• Development of highly sensitive and portable CRP detection devices is feasible.

Conclusions:

• Nanobiotechnology offers promising alternatives to conventional CRP assays like ELISA.
• Hybrid nanobio CRP biosensors represent a significant advancement in diagnostic capabilities.
• These novel biosensors pave the way for rapid, point-of-care inflammatory disease diagnostics.