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Enzyme activity and allosteric characteristics of gamma-irradiated solid aspartate transcarbamylase

W N Bigler, B M Tolbert

    Radiation Research
    |December 1, 1977
    PubMed
    Abstract

    No abstract available in PubMed .

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    Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
    Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...

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